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  • HPV - VPH
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HPV TEST

HPV TEST

HPV TEST HPV treatment The certain diagnose most be done by molecular biology.

Using molecular pathology techniques, the HPV test, unlike the Pap smear, allows us to have a precise diagnosis of the Human Papillomavirus. The Polymerase Chain Reaction (PCR) is a painless technique which involves the extraction of cellular material as it is done in a Pap smear but, unlike this, it has a sensitivity of 100% in the cervix. In other words, there is no possibility of false negatives if the extraction is correctly performed. This molecular biology technique, which we prefer and recommend, also gives us the possibility to find out which type of HPV the patient actually has. The importance of this lies in the fact that there are tumor viruses, in other words, viruses related to cancer such as: HPV 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 and 68, among others. There are other viruses related to benign warts which may result unsightly or contagious. This technique is also used in other genital areas such as the vagina, vulva, anus, penis or other parts of the body, which cannot be contagious, such as the mouth or areas of the skin near the genitals and different organs where the HPV infections are less frequent, on the other hand PCR lets us know if HPV vaccines will be preventive or not

Another currently used technique for detection of the HPV is the “hybrid-capture” test which gives us the possibility to obtain information about the human papillomaviruses connected to genital infection or cervix cancer as well as some benign viruses related to common warts. Unlike PCR, this technique does not report on the infectious type of viruses and it is only sensitive to the most frequently found viruses.

The “hybrid-capture” detects HPV viruses which are often found in the genitals. These one are classified in: Group I: 6, 11, 42, 43, 44, 53 and 54 called “low-risk” HPV types and which are not related to cancer; and Group II viruses, also called of “high-risk”: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 and 68 related cancer.

HPV (Human Papillomavirus), can be considered a transforming agent thus called tumoral viruses.

Tumoral viruses such as some types of HPV cause the transformation of a normal into a cancerous cell. This is a result of HPV  ability to integrate its genetic information (HPV DNA) into the nuclear DNA of the host cell. Some HPV oncoproteins play an important role in this transformation.

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